February 27 2017. On January 19, 2017, the journal Thorax reported the finding of researchers at Children’s Hospital Los Angeles’ Saban Institute of a protective effect for inhalable resveratrol against aging-related degenerative lung changes. Resveratrol, an antioxidant compound occurring in red grapes and wine, has been associated with a number of benefits in animals and humans. "We believe that ours is the first study to demonstrate a beneficial effect of resveratrol treatments on aging lung function," announced lead researcher Barbara Driscoll, PhD.The study involved a mouse model of premature aging, including accelerated aging of the lung. Resveratrol or a control substance were intratracheally instilled monthly for three months. Lung structure, function, DNA damage and survival of alveolar epithelial type cells that line the lungs’ alveoli were evaluated one month following the final treatment.
Dr Driscoll’s team observed a slower rate of lung decline, including a delay in alveolar enlargement and alveolar epithelial type 2 cell DNA damage, among mice that received resveratrol. They suggest that administering resveratrol to the lungs could help treat lung aging, which increases the risk of chronic lung disease.
"While the natural deterioration of the human lung generally occurs over decades, the injury to lung cells is analogous to the lung cell damage that occurs in premature infants who experience respiratory distress before their lungs have fully developed," Dr. Driscoll noted. "Identifying a way to protect and strengthen young lungs before significant damage occurs is the goal of our research."
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