Huperzine serrata extract | Huperzine A| 102518-79-6

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Huperzine A has been proven superior to drugs licensed for the treatment of Alzheimer’s, including the leading anticholine sterase drugs physostigmine and tacrine. Huperzine A improved learning and memory in mice better than tacrine. Unlike physostigmine and tacrine, Huperzine A acts specifically on AchE in the brain rather than AchE found elsewhere in the body i.e., far less is wasted on irrelevant effects. Unlike physostigmine and tacrine, Huperzine A does not appear to bind to receptors in the central nervous system, which can cause adverse side effects. Its effects last 10 to 12 times longer than physostigmine and tacrine (up to 8 hours).

Product name

Huperzia serrata extract

Part of plant used

Whole herb


1-98% Huperzine



* Huperzia serrata (TCM = Qian Ceng Ta/Jin Bu Huan) is a plant known as a firmoss which contains
the acetylcholinesterase inhibitor huperzine A. It is widely distributed over-the-counter as a nootropic and dietary supplement.
* This species is native to China, India and southeast Asia.
* Huperzine A is a reversible acetylcholinesterase inhibitor and NMDA receptor antagonist that
crosses the blood-brain barrier. A 2013 meta-analysis found that huperzine A may be efficacious in
improving cognitive function, global clinical status, and activities of daily living for individuals with Alzheimer’s disease.
*Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve
memory and mental function. Huperzine A may also have a possible role in the treatment of

Huperzine A is a substance extracted from a plant called Chinese club moss (Huperzia serrata). In traditional Chinese medicine, Chinese club moss has long been used to reduce inflammation and to sharpen memory. Sold as a dietary supplement, huperzine A is typically touted as a treatment for Alzheimer's disease.
Huperzine A is extracted from huperzia serrata.It is an acetylcholinesterase inhibititor and NMDA receptor antagonist.The structure of the complex of huperzine A with acetylcholinesterase has been determined by X-ray crystallography .
 For some years, Huperzine A has been investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer's disease. Although some research suggests it may be helpful, the evidence overall is not convincing enough for it to be recommended for use as a medicine, and little is known of its safety.
[Uses for Huperzine A]
Huperzine A has been found to act as a cholinesterase inhibitor, a type of medicine used to prevent the breakdown of acetylcholine (a chemical essential to learning and memory).
Not only used as a treatment for Alzheimer's disease, huperzine A is also said to enhance learning and memory and to protect against age-related cognitive decline.
In addition, huperzine A is sometimes used to boost energy, increase alertness, and aid in the treatment of myasthenia gravis (an autoimmune disorder that affects the muscles).
Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve memory and mental function.
[Benefits of Huperzine A]
While research on the health effects of huperzine A is fairly limited, there's some evidence that huperzine A may offer certain benefits. Here's a look at some key findings from the available research:
1) Alzheimer's Disease
2) Memory Enhancement

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